Standard Article

Epithelial Transport

Handbook of Physiology, Cell Physiology

  1. Luis Reuss

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp140108

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Reuss, L. 2011. Epithelial Transport. Comprehensive Physiology. 309–388.

Author Information

  1. Department of Physiology and Biophysics, The University of Texas Medical Branch, Galveston, Texas

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Transporting Epithelia Are Sheets of Polar Cells
    • 1.1
      Epithelial Structure Involves Specialized Cell–Cell and Cell–Matrix Junctions
    • 1.2
      Epithelial Polarity Is Essential for Vectorial Transport
  • 2
    Transporting Epithelia Generate and Maintain Differences in Chemical Composition Between Fluid Compartments
    • 2.1
      Transepithelial Transport Involves Active Ion Transport
    • 2.2
      Passive Transport Processes also Contribute to Transepithelial Transport
    • 2.3
      Transepithelial Transport Involves Transcellular and Paracellular Pathways
    • 2.4
      Chemical and Electrical Gradients Couple Ion Fluxes in Epithelia
  • 3
    The Building Blocks of Epithelial Function Are Membrane Transporters
  • 4
    Mechanisms of Ion Transport
    • 4.1
      The Two-Membrane Hypothesis: A General Epithelial-Transport Model
    • 4.2
      Mechanisms of Transepithelial NaCl Transport in Absorptive Epithelia
    • 4.3
      Mechanisms of Ion Transport in Primary Cl-Transporting Epithelia
    • 4.4
      Mechanisms of Ion Transport in H+ — and inline image-Transporting Epithelia
  • 5
    Mechanisms of Transepithelial Water Transport
    • 5.1
      Transepithelial Water Transport Is Linked to Transepithelial Salt Transport
    • 5.2
      Epithelia Are Widely Diverse in Their Water-Transport Characteristics
    • 5.3
      Transepithelial Water Transport in Leaky Epithelia Is Nearly Isosmotic
    • 5.4
      Transepithelial Water Transport in Leaky Epithelia Can Be Transcellular and/or Paracellular
    • 5.5
      Water Permeation across Cell Membranes of Some Leaky Epithelia Is via Constitutive Pores
    • 5.6
      Mechanisms of Transepithelial Water Transport in ADH-Sensitive Epithelia
    • 5.7
      Molecular Identity of Water Pores in Epithelial-Cell Membranes
  • 6
    Mechanisms of Regulation of Transepithelial Transport
    • 6.1
      Rapid Regulation
    • 6.2
      Long-term Regulation
    • 6.3
      Intramembrane Regulation and Cross-Talk Mechanisms