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The ER–Golgi Membrane System: Compartmental Organization and Protein Traffic

Handbook of Physiology, Cell Physiology

  1. Hans-Peter Hauri1,
  2. Anja Schweizer2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp140115

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Hauri, H.-P. and Schweizer, A. 2011. The ER–Golgi Membrane System: Compartmental Organization and Protein Traffic. Comprehensive Physiology. 605–647.

Author Information

  1. 1

    Department of Pharmacology, Biozentrum, University of Basel, Basel, Switzerland Hoffmann-La Roche, Basel, Switzerland

  2. 2

    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Organization of the ER-Golgi Membrane System
    • 1.1
      Endoplasmic Reticulum
    • 1.2
      Golgi Apparatus
    • 1.3
      ER-Golgi Intermediate Compartment
  • 2
    Anterograde (Exocytotic) Protein Traffic From ER to Golgi
    • 2.1
      Acquisition of Transport Competence in the ER
    • 2.2
      COPI- and COPII-Coated Transport Vesicles
    • 2.3
      Vesicle Docking and Fusion
    • 2.4
      GTPases
    • 2.5
      Role of the ERGIC in ER-to-Golgi Transport
  • 3
    Protein Retention and Retrieval
    • 3.1
      Membrane Flow, Selective Transport, and Protein Retention
    • 3.2
      Soluble ER proteins
    • 3.3
      ER and ERGIC Membrane Proteins
    • 3.4
      Golgi Membrane Proteins
  • 4
    Retrograde Protein Traffic
    • 4.1
      Insights from Brefeldin A
    • 4.2
      Recycling from the cis-Golgi
    • 4.3
      Role of the ERGIC and Possible Role of ERGIC-53
  • 5
    Regulation of Membrane Traffic in the Early Secretory Pathway and Maintenance of Organelle Structure
  • 6
    Conclusions and Prospects