Standard Article

Epithelial Cell Polarity: Challenges and Methodologies

Handbook of Physiology, Cell Physiology

  1. Michael J. Caplan1,
  2. Enrique Rodriguez-Boulan2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp140117

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Caplan, M. J. and Rodriguez-Boulan, E. 2011. Epithelial Cell Polarity: Challenges and Methodologies. Comprehensive Physiology. 665–688.

Author Information

  1. 1

    Department of Physiology, Yale University School of Medicine, New Haven, Connecticut

  2. 2

    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Questions
  • 2
    Tools and Techniques with Which to Study Epithelial Polarity
    • 2.1
      Epithelial Monolayers Grown on Permeable Substrata
    • 2.2
      Morphological Techniques
    • 2.3
      Biochemical Techniques
  • 3
    Protein Trafficking Pathways in Epithelial Cells
    • 3.1
      Biogenetic Pathways
    • 3.2
      Transcytosis
    • 3.3
      Recycling Pathways
    • 3.4
      Tissue-Specific Variation of Protein Polarity and Targeting Pathways in Epithelial Cells
  • 4
    Sorting Signals and Mechanisms
  • 5
    Establishment of Epithelial Polarity
    • 5.1
      The Role of E-Cadherin
  • 6
    Future Prospects: In Vitro Systems, Genetic Models, and the Search for Sorting Machinery