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Mechanisms of Transmembrane Signaling

Handbook of Physiology, Cell Physiology

  1. Kevin Wickman,
  2. Karen E. Hedin,
  3. Carmen M. Perez-Terzic,
  4. Grigory B. Krapivinsky,
  5. Lisa Stehno-Bittel,
  6. Bratislav Velimirovic,
  7. David E. Clapham

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp140118

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Wickman, K., Hedin, K. E., Perez-Terzic, C. M., Krapivinsky, G. B., Stehno-Bittel, L., Velimirovic, B. and Clapham, D. E. 2011. Mechanisms of Transmembrane Signaling. Comprehensive Physiology. 689–742.

Author Information

  1. Department of Pharmacology, Mayo Foundation, Rochester, Minnesota

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Signal Transduction via Heterotrimeric GTP-Binding Proteins
    • 1.1
      G Protein Coupled Receptors (GCRs)
    • 1.2
      Heterotrimeric GTP-Binding Proteins (G Proteins)
    • 1.3
      Diseases Linked to GCRs and G Proteins
    • 1.4
      Examples of G Protein–Regulated Effectors and Signaling Pathways
  • 2
    Signal Transduction via Receptor Tyrosine Kinases
    • 2.1
      Introduction to Receptor Tyrosine Kinases (RTKs)
    • 2.2
      Initial Steps of RTK Signal Transduction
    • 2.3
      Ras Activation by RTK
    • 2.4
      Ras Stimulates the MAPK Pathway Via Its Effector, Raf-1
    • 2.5
      RTK Signaling Mechanisms Are Used by Other Receptor Families
  • 3
    Mitogenic Crosstalk: GCRs, RTKs, and the MAPK Pathway
    • 3.1
      A GCR Induces Tyrosine Phosphorylation of SHC
    • 3.2
      Ras Activation by Gβγ
    • 3.3
      Gβγ Stimulation of MAPK in Yeast
    • 3.4
      i Stimulation of a MEK Kinase in Rat-1a Cells
    • 3.5
      GCR-Mediated Inhibition of Mitogenic Signaling
  • 4
    Conclusion