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Cellular Mechanisms During Mammalian Fertilization

Handbook of Physiology, Cell Physiology

  1. Paul M. Wassarman1,
  2. Harvey M. Florman2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp140124

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Wassarman, P. M. and Florman, H. M. 2011. Cellular Mechanisms During Mammalian Fertilization. Comprehensive Physiology. 885–938.

Author Information

  1. 1

    Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York

  2. 2

    Department of Anatomy and Cellular Biology, Tuffs University School of Medicine, Boston, Massachusetts

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    General Introduction
  • 2
    Oogenesis and Spermatogenesis
    • 2.1
      Oogenesis: Primordial Germ Cells to Eggs
    • 2.2
      Spermatogenesis: Primordial Germ Cells to Spermatozoa
  • 3
    Final Preparation of Gametes for Fertilization
    • 3.1
      Eggs: “Meiotic Maturation”
    • 3.2
      Regulatory Aspects of Oocyte Maturation
    • 3.3
      Sperm: “Capacitation”
    • 3.4
      Sperm Activity States
  • 4
    Binding of Sperm to Eggs
    • 4.1
      Structure of the Zona Pellucida
    • 4.2
      Identification of a Mammalian Sperm Receptor
    • 4.3
      Other Mammalian Sperm Receptors
  • 5
    The Acrosome Reaction
    • 5.1
      Anatomy of the Acrosome
    • 5.2
      Stages of Exocytosis
    • 5.3
      Functions of the Acrosome Reaction during Fertilization
    • 5.4
      Site of the Acrosome Reaction
    • 5.5
      Mechanisms of the Acrosome Reaction
    • 5.6
      Initiators of Exocytosis
    • 5.7
      Conclusions
    • 5.8
      Signaling at the Sperm Plasma Membrane
    • 5.9
      Mediators of Receptor-Activated Second-Messenger Production in Sperm
    • 5.10
      Second-Messenger Production
    • 5.11
      Ca2+ and Ca2+ Channels
    • 5.12
      Internal pH
    • 5.13
      Downstream Effectors of Receptor Activation
    • 5.14
      Gamete Fusion and Cortical Granule Exocytosis
    • 5.15
      Cortical Granules
    • 5.16
      Gamete Membrane Fusion and the Receptor Question
    • 5.17
      From Oolemma to Cortical Granule—Signal Transduction Pathways