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Keywords:

  • fluorescence;
  • nanoparticles;
  • nucleic acid detection;
  • sensors;
  • zeolitic imidazolate frameworks
Thumbnail image of graphical abstract

Stranded on a nanoparticle: For the first time, zeolitic imidazolate framework-8 nanoparticles (ZIFNPs) have been used in an effective fluorescent sensing platform for nucleic acids. The DNA detection is accomplished in two steps: 1) ZIFNPs adsorb and quench the dye-labeled single-stranded DNA probe, and 2) subsequent hybridization of the probe with its target produces double-stranded DNA, which detaches from the ZIFNP. The present system shows a high selectivity down to single-base mismatch (see figure).