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Application of Zeolitic Imidazolate Framework-8 Nanoparticles for the Fluorescence-Enhanced Detection of Nucleic Acids

Authors

  • Dr. Sen Liu,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Lei Wang,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Jingqi Tian,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039 (P. R. China)
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  • Yonglan Luo,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Guohui Chang,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Abdullah M. Asiri,

    1. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    2. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
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  • Abdulrahman O. Al-Youbi,

    1. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    2. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
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  • Prof. Xuping Sun

    Corresponding author
    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
    2. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    3. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    • State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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Abstract

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Stranded on a nanoparticle: For the first time, zeolitic imidazolate framework-8 nanoparticles (ZIFNPs) have been used in an effective fluorescent sensing platform for nucleic acids. The DNA detection is accomplished in two steps: 1) ZIFNPs adsorb and quench the dye-labeled single-stranded DNA probe, and 2) subsequent hybridization of the probe with its target produces double-stranded DNA, which detaches from the ZIFNP. The present system shows a high selectivity down to single-base mismatch (see figure).

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