Fast and Sensitive Colorimetric Detection of H2O2 and Glucose: A Strategy Based on Polyoxometalate Clusters

Authors

  • Dr. Sen Liu,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Jingqi Tian,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039 (P. R. China)
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  • Lei Wang,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Yingwei Zhang,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Yonglan Luo,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Haiyan Li,

    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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  • Abdullah M. Asiri,

    1. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    2. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
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  • Abdulrahman O. Al-Youbi,

    1. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    2. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
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  • Prof. Xuping Sun

    Corresponding author
    1. State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
    2. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    3. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)
    • State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin (P. R. China), Fax: (+86) 431-85262065
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Abstract

original image

Proof-of-concept: A polyoxometalate cluster has been used as a highly effective peroxidase mimetic to catalyze H2O2 oxidation of various peroxidase substrates to give colored solutions, leading to a simple, fast, sensitive, and selective assay for H2O2 with a linear range and detection limit of 1–20 and 0.4 μM. This assay was also used for glucose detection both in buffer solution and diluted serum with a linear range and detection limit of 1–10 and 0.5 μM.

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