Sequence-Specific Metallization of Single Divalent DNA–Nanoparticle Conjugates: A Potential Route to Single-Electron Devices

Authors

  • Guoqing Wang,

    1. Graduate School of Chemical Sciences and Engineering, Hokkaido University, N13W8, Kita-Ku, Sapporo 006-8628 (Japan)
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  • Ayako Ishikawa,

    1. Graduate School of Chemical Sciences and Engineering, Hokkaido University, N13W8, Kita-Ku, Sapporo 006-8628 (Japan)
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  • Asumi Eguchi,

    1. Graduate School of Chemical Sciences and Engineering, Hokkaido University, N13W8, Kita-Ku, Sapporo 006-8628 (Japan)
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  • Yasunobu Suzuki,

    1. Graduate School of Chemical Sciences and Engineering, Hokkaido University, N13W8, Kita-Ku, Sapporo 006-8628 (Japan)
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  • Dr. Shukichi Tanaka,

    1. Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Nishi-Ku, Kobe 651-2401 (Japan)
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  • Dr. Yasutaka Matsuo,

    1. Research Institute for Electronic Science, Hokkaido University, N21W10, Kita-Ku, Sapporo 001-0021 (Japan)
    2. Japan Science Technology Agency, CREST, Sanban-Cho 5, Chiyoda-Ku, Tokyo 102-0075 (Japan)
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  • Dr. Kenichi Niikura,

    1. Research Institute for Electronic Science, Hokkaido University, N21W10, Kita-Ku, Sapporo 001-0021 (Japan)
    2. Japan Science Technology Agency, CREST, Sanban-Cho 5, Chiyoda-Ku, Tokyo 102-0075 (Japan)
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  • Prof. Kuniharu Ijiro

    Corresponding author
    1. Research Institute for Electronic Science, Hokkaido University, N21W10, Kita-Ku, Sapporo 001-0021 (Japan)
    2. Japan Science Technology Agency, CREST, Sanban-Cho 5, Chiyoda-Ku, Tokyo 102-0075 (Japan)
    • Research Institute for Electronic Science, Hokkaido University, N21W10, Kita-Ku, Sapporo 001-0021 (Japan)
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Abstract

Although progress has been made in the construction of single-electron devices (SEDs), few of the reported approaches have proved practically applicable, mainly owing to their cost-ineffectiveness and need for sophisticated instrumentation. Herein, a conceptually new method for fabricating SEDs through the metallization of divalent DNA-nanoparticle conjugates is described. Specifically, divalent DNA copolymers that are conjugated to gold nanoparticles (AuNP) were synthesized by application of the enzymatic extension of DNA conjugated on quantum-sized AuNPs. This conjugate structure allows the distance between the resulting poly(dG)-poly(dC) and the AuNP to be controlled by an ssDNA spacer. To afford poly(dG)-poly(dC) sequence-specific metal deposition, Cisplatin capable of specific chemisorption on the poly(dG)-poly(dC) is incubated with the divalent DNA copolymer–AuNP conjugates, followed by reduction of the Cisplatin to Pt metal at base resolution. As a result, AuNPs separated from the Pt “electrodes” by the ssDNA barriers in a single conjugate could be created as a double-tunnel junction for SEDs. This study is thought to be an important step toward the programmable organization of DNA for use in SEDs.

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