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Sequence-Specific Metallization of Single Divalent DNA–Nanoparticle Conjugates: A Potential Route to Single-Electron Devices

  1. Guoqing Wang2,
  2. Ayako Ishikawa2,
  3. Asumi Eguchi2,
  4. Yasunobu Suzuki2,
  5. Dr. Shukichi Tanaka3,
  6. Dr. Yasutaka Matsuo1,4,
  7. Dr. Kenichi Niikura1,4,
  8. Prof. Kuniharu Ijiro1,4,*

Article first published online: 11 JUN 2012

DOI: 10.1002/cplu.201200096

Issue

ChemPlusChem

ChemPlusChem

Volume 77, Issue 7, pages 592–597, July 2012

Additional Information

How to Cite

Wang, G., Ishikawa, A., Eguchi, A., Suzuki, Y., Tanaka, S., Matsuo, Y., Niikura, K. and Ijiro, K. (2012), Sequence-Specific Metallization of Single Divalent DNA–Nanoparticle Conjugates: A Potential Route to Single-Electron Devices. ChemPlusChem, 77: 592–597. doi: 10.1002/cplu.201200096

Author Information

  1. 1

    Research Institute for Electronic Science, Hokkaido University, N21W10, Kita-Ku, Sapporo 001-0021 (Japan)

  2. 2

    Graduate School of Chemical Sciences and Engineering, Hokkaido University, N13W8, Kita-Ku, Sapporo 006-8628 (Japan)

  3. 3

    Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Nishi-Ku, Kobe 651-2401 (Japan)

  4. 4

    Japan Science Technology Agency, CREST, Sanban-Cho 5, Chiyoda-Ku, Tokyo 102-0075 (Japan)

*Research Institute for Electronic Science, Hokkaido University, N21W10, Kita-Ku, Sapporo 001-0021 (Japan)

Publication History

  1. Issue published online: 5 JUL 2012
  2. Article first published online: 11 JUN 2012
  3. Manuscript Revised: 24 MAY 2012
  4. Manuscript Received: 22 APR 2012

Funded by

  • MEXT, Japan
  • JSPS

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Keywords:

  • DNA recognition;
  • nanoparticles;
  • polymerization;
  • sequence-specific metallization;
  • single-electron devices

Abstract

Although progress has been made in the construction of single-electron devices (SEDs), few of the reported approaches have proved practically applicable, mainly owing to their cost-ineffectiveness and need for sophisticated instrumentation. Herein, a conceptually new method for fabricating SEDs through the metallization of divalent DNA-nanoparticle conjugates is described. Specifically, divalent DNA copolymers that are conjugated to gold nanoparticles (AuNP) were synthesized by application of the enzymatic extension of DNA conjugated on quantum-sized AuNPs. This conjugate structure allows the distance between the resulting poly(dG)-poly(dC) and the AuNP to be controlled by an ssDNA spacer. To afford poly(dG)-poly(dC) sequence-specific metal deposition, Cisplatin capable of specific chemisorption on the poly(dG)-poly(dC) is incubated with the divalent DNA copolymer–AuNP conjugates, followed by reduction of the Cisplatin to Pt metal at base resolution. As a result, AuNPs separated from the Pt “electrodes” by the ssDNA barriers in a single conjugate could be created as a double-tunnel junction for SEDs. This study is thought to be an important step toward the programmable organization of DNA for use in SEDs.

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