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Facile Functionalization of Colloidal Gold Nanorods by the Specific Binding of an Engineered Protein that Is Preferred over CTAB Bilayers

Authors

  • Won Min Park,

    1. Department of Chemical & Biomolecular Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
    2. Current address: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100 (USA)
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  • Dr. Bong Gill Choi,

    1. Department of Chemical & Biomolecular Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
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  • Dr. Yun Suk Huh,

    1. Division of Materials Science, Korea Basic Science Institute, 169-148 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Republic of Korea)
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  • Prof. Won Hi Hong,

    1. Department of Chemical & Biomolecular Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
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  • Prof. Sang Yup Lee,

    1. Department of Chemical & Biomolecular Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
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  • Prof. Tae Jung Park

    Corresponding author
    1. Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Republic of Korea)
    • Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Republic of Korea)
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Abstract

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Biomimetic functionalization: CTAB-covered gold nanorods were functionalized with an engineered GBP-SpA protein through its preferential binding on the gold surface, while colloidal stability was maintained through in situ removal of free CTAB. The functionalized GNRs could be used for plasmonic biosensing after conjugation of antibody through biomolecular recognition (see picture).

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