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Folic Acid Functionalized Nanoprobes for Fluorescence-, Dark-Field-, and Dual-Imaging-Based Selective Detection of Cancer Cells and Tissue

Authors

  • Amit Ranjan Maity,

    1. Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata 700032 (India), Fax: (+91) 33-24732805
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  • Arindam Saha,

    1. Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata 700032 (India), Fax: (+91) 33-24732805
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  • Dr. Arun Roy,

    1. Department of Microbiology, Vijaygarh Jyotish Ray College, University of Calcutta, Kolkata 700032 (India)
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  • Dr. Nikhil R. Jana

    Corresponding author
    1. Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata 700032 (India), Fax: (+91) 33-24732805
    • Centre for Advanced Materials, Indian Association for the Cultivation of Science, Kolkata 700032 (India), Fax: (+91) 33-24732805
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Abstract

Folate-functionalized quantum dots, gold/silver nanoparticles, and magnetic quantum dots have been synthesized and used as fluorescence, dark-field, and dual-imaging probes for the detection of cancer cells and tissues. A very efficient and generalized folate-functionalization method has been developed for various amine-terminated nanoparticles. The advantages of the presented approach are that it can be used to synthesize a wide range of folate-functionalized nanoparticles and the number of folate molecules per nanoparticle can be controlled easily to tune their interaction with folate receptors present at the cell surface. These folate-functionalized nanoparticles have been used as cellular and tissue-imaging bioprobes. Results show that folate-functionalized nanoparticles act as efficient and selective imaging probes in targeting cancer cells and tissues and labeled cells/tissues can be detected by using different imaging modalities.

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