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Keywords:

  • biocatalysis;
  • DOPA peptides;
  • enzymes;
  • immobilization;
  • synthetic methods

Abstract

3,4-Dihydroxyphenylalanine (DOPA)-containing peptides and proteins provide attractive design paradigms for pharmaceutical applications and engineering of synthetic polymers. An efficient and selective route to DOPA peptides by oxidation of L-tyrosine derivatives with tyrosinase is reported. The efficiency of the procedure was tested by using successively recycled tyrosinase immobilized on Eupergit®C250L and coated with polyelectrolytes by the layer-by-layer method.