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Keywords:

  • antitumor agents;
  • 2,7-disubstituted fluorenones;
  • docking;
  • 9-fluorenone-2-carboxylic acid;
  • tubulins

Abstract

The introduction of a hydrophobic group at position 7 of 9-fluorenone-2-carboxylic acid generates new tubulin binders, the design of which is suggested by modeling studies. The synthesis is based on the use of 2,7-dibromo-fluorenone as starting material. The antiproliferative activity on two different cell lines, fluorescent microscopy, flow cytometry, and sedimentation assay tests confirmed the supposed mechanism.