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Polyethyleneimine/Manganese-Doped ZnS Nanocomposites: A Multifunctional Probe for Two-Color Imaging and Three-Dimensional Sensing

Authors

  • Li-Jia Sang,

    1. State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071 (P.R. China), Fax: (+86) 22-23506075
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  • Ye-Yu Wu,

    1. State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071 (P.R. China), Fax: (+86) 22-23506075
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  • Dr. He-Fang Wang

    Corresponding author
    1. State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071 (P.R. China), Fax: (+86) 22-23506075
    • State Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071 (P.R. China), Fax: (+86) 22-23506075
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Abstract

We present herein a new single probe, polyethyleneimine (PEI)/Mn[BOND]ZnS nanocomposite, for two-color imaging and three-dimensional sensing. The PEI/Mn[BOND]ZnS nanocomposite possesses unique, individually excited, two-color, photoluminescence (PL) emissions at λ=495 and 585 nm; this allows two-color imaging of the same space just by changing the excitation wavelength in situ. Moreover, the two PL bands of the nanocomposite are orthogonal, which allows the discrimination of eight proteins just by recording the three-channel optical signals of the single probe. The two PL bands of the PEI/Mn[BOND]ZnS composite are capable of distinguishing eight proteins at 0.5 μM, whereas the three-channel signals (two PL bands and light scattering) can discriminate these proteins at no less than 0.25 μM.

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