Absolute Configuration and Antimalarial Activity of erythro-Mefloquine Enantiomers

Authors

  • Dr. Alexandra Dassonville-Klimpt,

    1. Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    Search for more papers by this author
  • Dr. Christine Cézard,

    1. Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    Search for more papers by this author
  • Dr. Catherine Mullié,

    1. Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    Search for more papers by this author
  • Dr. Patrice Agnamey,

    1. Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    Search for more papers by this author
  • Dr. Alexia Jonet,

    1. Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    Search for more papers by this author
  • Sophie Da Nascimento,

    1. Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    Search for more papers by this author
  • Dr. Mathieu Marchivie,

    1. CNRS FRE 3396-Pharmacochimie, UFR de Pharmacie, Université Bordeaux Segalen, 33076 Bordeaux cedex (France)
    Search for more papers by this author
  • Prof. Dr. Jean Guillon,

    1. CNRS FRE 3396-Pharmacochimie, UFR de Pharmacie, Université Bordeaux Segalen, 33076 Bordeaux cedex (France)
    Search for more papers by this author
  • Prof. Dr. Pascal Sonnet

    Corresponding author
    1. Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    • Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1, rue des Louvels, 80037 Amiens cedex 01 (France), Fax: (+33) 322827469
    Search for more papers by this author

Abstract

original image

Mefloquine (MQ), an antimalarial drug, is used as a racemate of (−)- and (+)-enantiomers, which display biological differences. The question concerning their exact configuration remains a matter of debate. The absolute configuration of the two MQ enantiomers as well as their biological activity has been established, thus confirming the importance of the stereochemistry in the design of MQ analogues that have fewer adverse side effects (see figure).

Ancillary