Liposomes for Improved Enzymatic Glycosylation of Lipid-Modified Lactose Enkephalin

Authors

  • Dr. Michelle P. Christie,

    1. School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St Lucia, QLD 4072 (Australia), Fax: (+61) 7-33654273
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  • Dr. Pavla Simerska,

    1. School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St Lucia, QLD 4072 (Australia), Fax: (+61) 7-33654273
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  • Dr. Freda E.-C. Jen,

    1. Institute for Glycomics, Griffith University, Parklands Drive, Southport, QLD 4125 (Australia)
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  • Prof. Michael P. Jennings,

    1. Institute for Glycomics, Griffith University, Parklands Drive, Southport, QLD 4125 (Australia)
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  • Prof. Istvan Toth

    Corresponding author
    1. School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St Lucia, QLD 4072 (Australia), Fax: (+61) 7-33654273
    2. School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Cornwall Street, Woolloongabba, QLD 4102 (Australia)
    • School of Chemistry and Molecular Biosciences, The University of Queensland, Cooper Road, St Lucia, QLD 4072 (Australia), Fax: (+61) 7-33654273
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Abstract

original image

Liposomes and enzymes: Liposome formulations improved solubility of a lipid-modified lactose enkephalin and, when used in enzymatic transformation, led to a twofold increase in glycosylation in comparison to substrate solubilised in 5 % dimethyl sulfoxide (DMSO; see figure).

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