Arginine Wettability and Impedance Dual-Signal Response by Aldehyde Calix[4]arene Self-Assembled Monolayers

Authors

  • Lanlan Yang,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423
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  • Li Luo,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423
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  • Guifen Zhang,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423
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  • Fajun Miao,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423
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  • Xiaoyan Zhang,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423
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  • Dr. Demei Tian,

    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423
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  • Prof. Dr. Haibing Li

    Corresponding author
    1. Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423
    • Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079 (P. R. China), Fax: (+86) 27-67866423

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Abstract

A new aldehyde calix[4]arene (C4AH) was synthesized efficiently to give a yield of 90 % and was used to form self-assembled monolayers (SAMS) by means of click chemistry to give a highly selective wettability and impedance sensor for arginine (Arg). The success of the C4AH functional interface and Arg-responsive events were confirmed by contact-angle (CA) measurements and electrochemical impedance spectroscopy (EIS). Furthermore, the C4AH functional interface can be used as wettability-responsive cycles at least eight times. This type of sensor operates on the principle that Arg has a high pKa value of 12.48, and is able to form strong hydrogen bonds with aldehyde selectivity, which results in a significant CA change. The proposed wettability-sensing devices display a remarkable specificity, intuitiveness, and convenience, which should be suitable for the production of arginine recognition chips that can be used in the fields of biology and medical science.

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