Encapsulated Ruthenium(II) Complexes in Biocompatible Poly(d,l-lactide-co-glycolide) Nanoparticles for Application in Photodynamic Therapy

Authors

  • Gaëlle Bœuf,

    1. ICMR–UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43
    2. Laboratoire de Recherche en Nanosciences, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France)
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  • Gaëlle V. Roullin,

    1. ICMR–UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43
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  • Dr. Juliette Moreau,

    1. ICMR–UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43
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  • Laurence Van Gulick,

    1. Laboratoire Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), FRE CNRS 3481, Champagne Ardenne, Reims (France)
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  • Dr. Nebraska Zambrano Pineda,

    1. Laboratoire de Recherche en Nanosciences, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France)
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  • Dr. Christine Terryn,

    1. Plate-forme IBISA, SFR CAP-SANTE, Université de Reims, Champagne Ardenne, Reims (France)
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  • Prof. Dominique Ploton,

    1. Plate-forme IBISA, SFR CAP-SANTE, Université de Reims, Champagne Ardenne, Reims (France)
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  • Prof. Marie Christine Andry,

    1. ICMR–UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43
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  • Prof. Françoise Chuburu,

    1. ICMR–UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43
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  • Dr. Sylvain Dukic,

    1. Laboratoire Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), FRE CNRS 3481, Champagne Ardenne, Reims (France)
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  • Prof. Michaël Molinari,

    1. Laboratoire de Recherche en Nanosciences, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France)
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  • Prof. Gilles Lemercier

    Corresponding author
    1. ICMR–UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43
    2. GDR CNRS no. 3049 “Photomed”
    • ICMR–UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43

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Abstract

The elaboration, characterisation and efficiency of potential two-photon-excited photodynamic therapy (PDT) treatment of new poly(d,l-lactide-co-glycolide) nanoparticles loaded with ruthenium(II) complexs are presented. The materials are based on the encapsulation of RuII complexes through an all-biocompatible process. The size of the nanoparticles is around 100 nm. The internal concentration is several orders of magnitude higher than the overall concentration, which leads to a more efficient and targeted effect. The therapeutic potential for PDT of these nanoparticles has been studied in vitro on C6 glioma cells.

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