Azahelicene Superbases as MAILD Matrices for Acidic Analytes

Authors

  • Mayuri Napagoda,

    1. Mass Spectrometry/Proteomics Research Group, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745 Jena (Germany), Fax: (+49) 3641-571701
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  • Dr. Lubomír Rulíšek,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Andrej Jančařík,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Jiří Klívar,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Michal Šámal,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Dr. Irena G. Stará,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Dr. Ivo Starý,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Dr. Veronika Šolínová,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Dr. Václav Kašička,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
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  • Dr. Aleš Svatoš

    Corresponding author
    1. Mass Spectrometry/Proteomics Research Group, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745 Jena (Germany), Fax: (+49) 3641-571701
    2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578
    • Mass Spectrometry/Proteomics Research Group, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745 Jena (Germany), Fax: (+49) 3641-571701
    Search for more papers by this author

  • MAILD=matrix-assisted ionisation/laser desorption.

Abstract

original image

Fitting the profile: A superbasic 1,14-diaza[5]helicene can serve as an efficient, ionless matrix for matrix-assisted ionization/laser desorption (MAILD) spectrometry. The matrix outperforms other bases by acting as a kinetically active proton sponge and is highly suitable for high-throughput metabolomics analysis. There is a correlation between the basicity (and proton-sponge character) of matrices and their efficacy in MAILD-MS.

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