Functionalized Porphyrins as Red Fluorescent Probes for Metal Cations: Spectroscopic, MALDI-TOF Spectrometry, and Doped-Polymer Studies

Authors

  • Dr. Nuno M. M. Moura,

    1. Department of Chemistry and QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal, Fax: (+351) 234-370-084
    2. BIOSCOPE Group, REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, 2829-516, Monte da Caparica, Portugal, Fax: (+351) 212-948-550
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  • Dr. Cristina Núñez,

    1. BIOSCOPE Group, REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, 2829-516, Monte da Caparica, Portugal, Fax: (+351) 212-948-550
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  • Dr. Sérgio M. Santos,

    1. Department of Chemistry and CICECO, University of Aveiro, A Campus de Santiago, 3810-193 Aveiro, Portugal
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  • Prof. M. Amparo F. Faustino,

    1. Department of Chemistry and QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal, Fax: (+351) 234-370-084
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  • Prof. José A. S. Cavaleiro,

    1. Department of Chemistry and QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal, Fax: (+351) 234-370-084
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  • Prof. M. Graça P. M. S. Neves,

    Corresponding author
    1. Department of Chemistry and QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal, Fax: (+351) 234-370-084
    • M. Graça P. M. S. Neves, Department of Chemistry and QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal, Fax: (+351) 234-370-084

      Carlos Lodeiro, BIOSCOPE Group, REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, 2829-516, Monte da Caparica, Portugal, Fax: (+351) 212-948-550

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  • Prof. José Luis Capelo,

    1. BIOSCOPE Group, REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, 2829-516, Monte da Caparica, Portugal, Fax: (+351) 212-948-550
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  • Prof. Carlos Lodeiro

    Corresponding author
    1. BIOSCOPE Group, REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, 2829-516, Monte da Caparica, Portugal, Fax: (+351) 212-948-550
    • M. Graça P. M. S. Neves, Department of Chemistry and QOPNA, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal, Fax: (+351) 234-370-084

      Carlos Lodeiro, BIOSCOPE Group, REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, 2829-516, Monte da Caparica, Portugal, Fax: (+351) 212-948-550

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Abstract

Invited for this month’s cover are groups from the University of Aveiro and the University NOVA of Lisbon/Bioscope. The cover picture of the lighthouses of Barra (Aveiro) and Cabo Espichel (Lisbon) in Portugal represents the remarkable sensing ability of benzoporphyrin derivatives for Hg2+ metal ions. These systems have high potential for use as chromogenic and fluorogenic sensors. Read the full text of the article on page 1230.

How did the collaboration on this project start?

1Our collaboration was established to exploit the expertise of the Aveiro group in the synthesis and functionalization of porphyrin derivatives as well as the skills of the Bioscope group in photophysical studies and development of new fluorescent chemosensors in the form of doped polymers having excellent emission properties.

Scheme 1.

M. A. F. Faustino, N. M. M. Moura, M. G. P. M. S. Neves, J. A. S. Cavaleiro, S. M. Santos, C. Núñez, C. Lodeiro, J. L. Capelo

What is the most significant result of this study?

The surprising ability of benzoporphyrin compounds, a π-extended porphyrin derivative, to detect Hg2+ in solution with a significant enhancement in the emission intensity. These compounds also showed the capacity to recognize metal cations when immobilized in PMMA films.

What prompted you to investigate this topic?

The need to develop new, efficient, and selective chemosensors for monitoring metal ions is important because of the increasing amount of metal-based pollutants in the environment. Detection of metal ions is also pertinent in biological processes because of the vital role that some metal ions such as Zn2+ play in living organisms.

What other topics are you working on at the moment?

Our two groups are interested in the development of new emissive and nanostructured materials based in porphyrinic derivatives for application as biomarkers, which can be attached in nanoparticles and nanomaterials.

Acknowledgements

We are grateful to the Universidade de Aveiro, Fundação para a Ciência e a Tecnologia (FCT), FEDER, and Portuguese National NMR Network. We also thank the Xunta de Galicia (Spain) and Scientific PROTEOMASS Association (Portugal) for financial support. Nuno Moura, Cristina Núñez, and Sérgio Santos thank FCT/MEC for postdoctoral grants.

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