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Fluorescent Nanodiamonds with Bioorthogonally Reactive Protein-Resistant Polymeric Coatings

Authors

  • Dr. Ivan Rehor,

    1. Institute of Organic Chemistry and Biochemistry, v.v.i. The Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 www.petrcigler.cz
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  • Dr. Hana Mackova,

    1. Institute of Macromolecular Chemistry, v.v.i. The Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Prague 6 (Czech Republic), Fax: (+420) 296-809-410
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  • Dr. Sergey K. Filippov,

    1. Institute of Macromolecular Chemistry, v.v.i. The Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Prague 6 (Czech Republic), Fax: (+420) 296-809-410
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  • Dr. Jan Kucka,

    1. Institute of Macromolecular Chemistry, v.v.i. The Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Prague 6 (Czech Republic), Fax: (+420) 296-809-410
    2. Nuclear Physics Institute, v.v.i. The Academy of Sciences of the Czech Republic, 250 68 Rez near Prague (Czech Republic)
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  • Dr. Vladimir Proks,

    1. Institute of Macromolecular Chemistry, v.v.i. The Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Prague 6 (Czech Republic), Fax: (+420) 296-809-410
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  • Jitka Slegerova,

    1. Institute of Organic Chemistry and Biochemistry, v.v.i. The Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 www.petrcigler.cz
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  • Dr. Stuart Turner,

    1. EMAT, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium)
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  • Prof. Gustaaf Van Tendeloo,

    1. EMAT, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium)
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  • Dr. Miroslav Ledvina,

    1. Institute of Organic Chemistry and Biochemistry, v.v.i. The Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 www.petrcigler.cz
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  • Dr. Martin Hruby,

    Corresponding author
    1. Institute of Macromolecular Chemistry, v.v.i. The Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Prague 6 (Czech Republic), Fax: (+420) 296-809-410
    • Martin Hruby, Institute of Macromolecular Chemistry, v.v.i. The Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Prague 6 (Czech Republic), Fax: (+420) 296-809-410

      Petr Cigler, Institute of Organic Chemistry and Biochemistry, v.v.i. The Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 www.petrcigler.cz

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  • Dr. Petr Cigler

    Corresponding author
    1. Institute of Organic Chemistry and Biochemistry, v.v.i. The Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 www.petrcigler.cz
    • Martin Hruby, Institute of Macromolecular Chemistry, v.v.i. The Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Prague 6 (Czech Republic), Fax: (+420) 296-809-410

      Petr Cigler, Institute of Organic Chemistry and Biochemistry, v.v.i. The Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 www.petrcigler.cz

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Abstract

The novel synthesis of a polymeric interface grown from the surface of bright fluorescent nanodiamonds is reported. The polymer enables bioorthogonal attachment of various molecules by click chemistry; the particles are resistant to nonspecific protein adsorption and show outstanding colloidal stability in buffers and biological media. The coating fully preserves the unique optical properties of the nitrogen-vacancy centers that are crucial for bioimaging and sensoric applications.

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