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Keywords:

  • circular dichroism;
  • click chemistry;
  • liposomes;
  • peptides;
  • self-assembly

Abstract

The random-coil-to-β-sheet transition of the (Leu-Glu)4 peptide motif is induced upon its conjugation to the liposome surface through “click” chemistry. Circular dichroism (CD) spectroscopy enables the in situ monitoring of this reaction. A change in the peptide secondary structure is already observed within 15 min. The β-sheet conformation becomes the dominant secondary structure after 45 min, as shown by the strong CD signal observed, which is typical for a β-sheet peptide secondary structure.