Cover Picture: Assembly Dependent Fluorescence Enhancing Nucleic Acids in Sequence-Specific Detection of Double-Stranded DNA (ChemPlusChem 1/2014)

Authors

  • Dr. Osman Doluca,

    1. College of Sciences, Institute of Fundamental Sciences, Massey University, Private Bag 11-222, 4442 Palmerston North (New Zealand), Fax: (+64) 6-3505682
    2. International Burch University, Francuske Revolucije, 71210 Sarajevo (Bosnia and Herzegovina)
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  • Dr. Tracy K. Hale,

    1. College of Sciences, Institute of Fundamental Sciences, Massey University, Private Bag 11-222, 4442 Palmerston North (New Zealand), Fax: (+64) 6-3505682
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  • Dr. Patrick J. B. Edwards,

    1. College of Sciences, Institute of Fundamental Sciences, Massey University, Private Bag 11-222, 4442 Palmerston North (New Zealand), Fax: (+64) 6-3505682
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  • Prof. Dr. Carlos González,

    1. Instituto de Química Física Rocasalano, CSIC, Serrano 119, 28006 Madrid (Spain)
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  • Dr. Vyacheslav V. Filichev

    Corresponding author
    1. College of Sciences, Institute of Fundamental Sciences, Massey University, Private Bag 11-222, 4442 Palmerston North (New Zealand), Fax: (+64) 6-3505682
    • College of Sciences, Institute of Fundamental Sciences, Massey University, Private Bag 11-222, 4442 Palmerston North (New Zealand), Fax: (+64) 6-3505682

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Abstract

original image

The cover picture shows a DNA strand forming a highly stable G-quadruplex that can be converted into an efficient DNA triplex-forming oligonucleotide by incorporating a pyrene intercalator into the sequence. Further modification by a thiazole orange derivative results in a highly fluorescent DNA triplex that is formed even in the presence of complementary RNA. These properties pave the way to visualise genes in a sequence specific manner via DNA triplex formation in live cells. Further details can be found in the Full Paper on page 58 by Vyacheslav V. Filichev, Carlos González and co-workers.

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