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Keywords:

  • click chemistry;
  • DNA recognition;
  • gene visualization;
  • G-quadruplexes;
  • nucleic acids;
  • triplex-forming oligonucleotides
Thumbnail image of graphical abstract

The cover picture shows a DNA strand forming a highly stable G-quadruplex that can be converted into an efficient DNA triplex-forming oligonucleotide by incorporating a pyrene intercalator into the sequence. Further modification by a thiazole orange derivative results in a highly fluorescent DNA triplex that is formed even in the presence of complementary RNA. These properties pave the way to visualise genes in a sequence specific manner via DNA triplex formation in live cells. Further details can be found in the Full Paper on page 58 by Vyacheslav V. Filichev, Carlos González and co-workers.