Anticancer Activity of Half-Sandwich RhIII and IrIII Metalla-Prisms Containing Lipophilic Side Chains

Authors

  • Dr. Gajendra Gupta,

    1. Institute of Chemistry, University of Neuchatel, Ave. de Bellevaux 51, 2000 Neuchatel (Switzerland)
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  • Dr. Jerald Mahesh Kumar,

    1. CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007 (India)
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  • Amine Garci,

    1. Institute of Chemistry, University of Neuchatel, Ave. de Bellevaux 51, 2000 Neuchatel (Switzerland)
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  • Nandini Rangaraj,

    1. CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007 (India)
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  • Dr. Narayana Nagesh,

    Corresponding author
    1. CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007 (India)
    • Narayana Nagesh, CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007 (India)

      Bruno Therrien, Institute of Chemistry, University of Neuchatel, Ave. de Bellevaux 51, 2000 Neuchatel (Switzerland)

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  • Prof. Dr. Bruno Therrien

    Corresponding author
    1. Institute of Chemistry, University of Neuchatel, Ave. de Bellevaux 51, 2000 Neuchatel (Switzerland)
    • Narayana Nagesh, CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007 (India)

      Bruno Therrien, Institute of Chemistry, University of Neuchatel, Ave. de Bellevaux 51, 2000 Neuchatel (Switzerland)

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Abstract

Two hexacationic pentamethylcyclopentadienyl rhodium(III) and iridium(III) metalla-prisms, [(η5-C5Me5)6M63-tpt-κN)24-C6HRO4O)3]6+ (tpt=2,4,6-tri-(pyridin-4-yl)-1,3,5-triazine; R=(CH2)10CH3; M=Rh, [3]6+; M=Ir, [4]6+) isolated as their triflate salts, have been synthesised from the dinuclear complexes (η5-C5Me5)2M24-C6HRO4O)Cl2 (M=Rh, 1; M=Ir, 2) and AgCF3SO3. The antiproliferative activity of the neutral and cationic complexes has been evaluated in vitro in human cancer cell lines. The positively charged metalla-prisms appear to target mitochondria, which ultimately induce apoptosis in cancer cells. All biological studies suggest that the rhodium derivative [3][CF3SO3]6 possesses excellent activities, not only in vitro but also in vivo in tumour-induced C57L6/J mice.

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