The frontispiece shows metal-mediated base pairing, where the hydrogen bonds present in natural base pairs are formally replaced by coordinative bonds to metal ions located along the helical axis. These base pairs can be made by introducing artificial ligand-based nucleosides into the nucleic acid sequence. In the presence of suitable transition-metal ions, these metal ions will site-specifically bind to the nucleic acid. As a result, DNA can be used as a supramolecular scaffold for metal-based functionality, adding new physical properties to this biomacromolecule. The latest developments in this field are highlighted in the Review by Philipp Scharf and Jens Müller on page 20 ff.