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The frontispiece shows (in blue) a superfluid helium nanodroplet in which, after collisions with fullerene vapor, a dimer is formed. CH4, H2O or other molecules are added upon subsequent collisions. What are the adsorption sites and energies? Do molecules prefer hollow sites at the centers of carbon rings? The groove region of the dimer (pictured as a ring)? How many molecules fit into the groove, how many into a complete solvation layer? Or do they grow islands? These questions are addressed in the Minireview by O. Echt,. P. Scheier and co-workers on page 910 ff. by using mass spectrometry combined with quantum chemical calculations. Implications range from storage of hydrogen-rich gases to the origin of spectral absorption features in interstellar space, represented by the image of the tarantula nebula (http://www.eso.org/public/images/).