ChemPlusChem

Cover image for Vol. 77 Issue 7

July 2012

Volume 77, Issue 7

Pages 497–597

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Review
    7. Minireview
    8. Communications
    9. Full Papers
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      Cover Picture: Polypyridyl Complexes of Ruthenium(II): Stabilization of G-quadruplex DNA and Inhibition of Telomerase Activity (ChemPlusChem 7/2012) (page 497)

      Dr. Du Liu, Yanan Liu, Chuan Wang, Prof. Shuo Shi, Dongdong Sun, Dr. Feng Gao, Prof. Qianling Zhang and Prof. Jie Liu

      Article first published online: 5 JUL 2012 | DOI: 10.1002/cplu.201290029

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      The cover picture shows a RuII polypyridyl complex with 1,10-phenanthroline as an ancillary ligand, which can target the telomeric DNA sequence at the ends of chromosomes and stabilize the telomeric G-quadruplex through multiple interactions (mainly intercalating) with the G-tetrad by the 3′-terminal face, and thus exhibit considerable inhibitory activity for telomerase and cancer cells. In their Full Paper on page 551 ff, J. Liu and co-workers report on how the design of RuII complexes that target and stabilize the telomeric G-quadruplex is a rational and promising approach to interfere with telomerase activity in tumor cells and to act as potential anticancer agents.

  2. Masthead

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    3. Masthead
    4. Graphical Abstract
    5. News
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    7. Minireview
    8. Communications
    9. Full Papers
    1. Masthead: ChemPlusChem 7/2012 (page 498)

      Article first published online: 5 JUL 2012 | DOI: 10.1002/cplu.201290030

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Review
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    8. Communications
    9. Full Papers
    1. Graphical Abstract: ChemPlusChem 7/2012 (pages 499–503)

      Article first published online: 5 JUL 2012 | DOI: 10.1002/cplu.201290031

  4. News

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    3. Masthead
    4. Graphical Abstract
    5. News
    6. Review
    7. Minireview
    8. Communications
    9. Full Papers
  5. Review

    1. Top of page
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    4. Graphical Abstract
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    1. Quantitative Structure–Activity/Property Relationships: The Ubiquitous Links between Cause and Effect (pages 507–517)

      Workalemahu M. Berhanu, Girinath G. Pillai, Alexander A. Oliferenko and Prof. Alan R. Katritzky

      Article first published online: 4 JUN 2012 | DOI: 10.1002/cplu.201200038

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      A flow chart to success: Screening of vast chemical spaces at high screening rates is what makes QSAR/QSPR an affordable and highly productive method provided important issues such as the applicability range and model validation are properly taken into account. This Review unfolds the story of QSAR used not only in drug design, but also in many other areas including materials design and nanotechnology (see figure).

  6. Minireview

    1. Top of page
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    3. Masthead
    4. Graphical Abstract
    5. News
    6. Review
    7. Minireview
    8. Communications
    9. Full Papers
    1. Organic Solid-State Fluorescence: Strategies for Generating Switchable and Tunable Fluorescent Materials (pages 518–531)

      Savarimuthu Philip Anthony

      Article first published online: 8 JUN 2012 | DOI: 10.1002/cplu.201200073

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      Give us a tune! Switching and tuning photophysical properties, particularly the solid-state fluorescence of small organic molecules, has attracted great attention owing to the recent emergence of optoelectronic technologies. The strategies (see figure) that have been used effectively to modify the solid-state fluorescence properties are discussed in this Review.

  7. Communications

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    4. Graphical Abstract
    5. News
    6. Review
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    8. Communications
    9. Full Papers
    1. Nine-Atom Tin-Bismuth Clusters: Mimicking Excess Electrons by Element Substitution (pages 532–535)

      Dipl.-Ing. Sven Heiles, Dr. Kathrin Hofmann, Prof. Dr. Roy L. Johnston and Prof. Dr. Rolf Schäfer

      Article first published online: 9 MAY 2012 | DOI: 10.1002/cplu.201200085

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      Avoiding negative charge: Combined experimental and theoretical evidence shows that neutral, nine-atom tin-bismuth clusters adopt structures of closely related tin (poly)anions (see figure; Sn gray, Bi blue). These clusters exhibit similar bonding arrangements as known from Zintl ions. Hence, element substitution can be used to eliminate the negative charge without affecting the bonding or structural motif.

    2. Sol-Gel Microencapsulation of Organic Molecules: A Structural and Chemical Insight (pages 536–540)

      Alexandra Fidalgo, Rosaria Ciriminna, Prof. Laura M. Ilharco, Marzia Sciortino and Dr. Mario Pagliaro

      Article first published online: 21 MAY 2012 | DOI: 10.1002/cplu.201200077

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      By analysis of diffuse-reflectance infrared Fourier transform spectroscopy results obtained from core/shell particles, the entrapment of bergamot oil (BO) and benzoyl peroxide (BPO) was compared in different silica and organosilica shells obtained from oil-in-water microemulsions (see spectra). The results point to a number of significant findings on the modality of the sol-gel microencapsulation process.

    3. Fast and Sensitive Colorimetric Detection of H2O2 and Glucose: A Strategy Based on Polyoxometalate Clusters (pages 541–544)

      Dr. Sen Liu, Jingqi Tian, Lei Wang, Yingwei Zhang, Yonglan Luo, Haiyan Li, Abdullah M. Asiri, Abdulrahman O. Al-Youbi and Prof. Xuping Sun

      Article first published online: 30 APR 2012 | DOI: 10.1002/cplu.201200051

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      Proof-of-concept: A polyoxometalate cluster has been used as a highly effective peroxidase mimetic to catalyze H2O2 oxidation of various peroxidase substrates to give colored solutions, leading to a simple, fast, sensitive, and selective assay for H2O2 with a linear range and detection limit of 1–20 and 0.4 μM. This assay was also used for glucose detection both in buffer solution and diluted serum with a linear range and detection limit of 1–10 and 0.5 μM.

  8. Full Papers

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Review
    7. Minireview
    8. Communications
    9. Full Papers
    1. Environmentally Friendly Photocatalytic Synthesis of Porphyrin/Ag Nanoparticles/Reduced Graphene Oxide Ternary Nanohybrids Having Superior Catalytic Activity (pages 545–550)

      Dr. Haiyan Li, Yingwei Zhang, Guohui Chang, Dr. Sen Liu, Jingqi Tian, Yonglan Luo, Prof. Abdullah M. Asiri, Abdulrahman O. Al-Youbi and Prof. Xuping Sun

      Article first published online: 24 APR 2012 | DOI: 10.1002/cplu.201200074

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      The first synthesis of novel organic/inorganic ternary nanohybrids of tin(IV) prophyrin (SnPor), Ag nanoparticles (AgNPs), and reduced graphene oxide (RGO) has been achieved by an environmentally friendly phtotcatalytic process using SnPor as a photocatalyst for the reduction of both GO and AgI. The nanohybrids show good catalytic activity in the degradation of rhodamine B under visible light (λ>400 nm, scheme of degradation by nanohybrids).

    2. Polypyridyl Complexes of Ruthenium(II): Stabilization of G-quadruplex DNA and Inhibition of Telomerase Activity (pages 551–562)

      Dr. Du Liu, Yanan Liu, Chuan Wang, Prof. Shuo Shi, Dongdong Sun, Dr. Feng Gao, Prof. Qianling Zhang and Prof. Jie Liu

      Article first published online: 21 MAY 2012 | DOI: 10.1002/cplu.201200039

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      Hot property: The spectroscopic, biochemical, and cellular properties of [Ru(phen)2(tip)](ClO4)2 (1) and [Ru(bpy)2(tip)](ClO4)2 (2) were examined to reveal their interactions with telomeric G-tetrad DNA and a relationship between the inhibition of telomerase and antitumor activity. Complex 1 exhibits high binding affinity (1.43×106M−1) and superior G-tetrad selectivity over duplex DNA through multiple interactions (mainly intercalating) with the G-tetrad (RuII complex is shown in yellow) at the 3'-terminal face.

    3. Scandium-Catalyzed Preparation of Cytotoxic 3-Functionalized Quinolin-2-ones: Regioselective Ring Enlargement of Isatins or Imino Isatins (pages 563–569)

      Prof. Dr. Benito Alcaide, Dr. Pedro Almendros, Dr. Cristina Aragoncillo, Dipl.-Chem. Gonzalo Gómez-Campillos, Prof. Dr. Manuel Arnó and Prof. Dr. Luis R. Domingo

      Article first published online: 23 MAY 2012 | DOI: 10.1002/cplu.201200090

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      Ring expansion of isatins: A variety of 3-hydroxy (or 3-amino) quinolin-2-one derivatives have been prepared through scandium-catalyzed controlled ring expansion of isatins or imino isatins by reaction with trimethylsilyldiazomethane (see scheme). Moreover, density functional calculations and cytotoxic studies were performed to obtain insights into both the reaction mechanism and the biological activity, respectively.

    4. Fabrication of High Energy-Density Hybrid Supercapacitors Using Electrospun V2O5 Nanofibers with a Self-Supported Carbon Nanotube Network (pages 570–575)

      Dr. Vanchiappan Aravindan, Yan Ling Cheah, Wai Fatt Mak, Dr. Grace Wee, Prof. Bobba V. R. Chowdari and Prof. Srinivasan Madhavi

      Article first published online: 3 MAY 2012 | DOI: 10.1002/cplu.201200023

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      A hybrid electrochemical capacitor (HEC) was fabricated using electrospun V2O5 coupled with single-walled carbon nanotubes. Cyclic voltammetry analysis reveals the supercapacitive behavior and galvanostatic charge-discharge studies show very stable cycle ability (given in figure and background shows SEM image of as-spun V2O5 nanofibers). Applied currents of 30–210 mA g−1 delivers maximum energy and power densities of 18 Wh kg−1 and 315 W kg−1, respectively.

    5. Surface Functionalization of Iron Oxide Nanoparticles and their Stability in Different Media (pages 576–583)

      Darius Arndt, Prof. Thorsten M. Gesing and Prof. Marcus Bäumer

      Article first published online: 29 MAY 2012 | DOI: 10.1002/cplu.201200065

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      Colloidal stability: Iron oxide nanoparticles have been synthesized by a simple one-pot reaction and functionalized with molecules such as citrate, ascorbate and tartrate, sugars (dextran, gum Arabic), and polymers (PVP, PEG; see figure). An additional synthesis step allows tagging of the PVP-stabilized particles with fluorescent markers. Tests show excellent colloidal stability in biological and environmentally relevant media. Depending on the functionalization, an acceleration of the Fenton reaction was observed.

    6. Cyclen-Based Cationic Lipids Containing Carbamate Linkages as Efficient Gene Delivery Vectors with Low Toxicity (pages 584–591)

      Dr. Qing-Dong Huang, Jiang Ren, Hong Chen, Wen-Jing Ou, Dr. Ji Zhang, Yun Fu, Prof. Dr. Wen Zhu and Prof. Dr. Xiao-Qi Yu

      Article first published online: 31 MAY 2012 | DOI: 10.1002/cplu.201200060

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      Ready for delivery: Two novel cationic lipids based on protonated cyclen and steroid (cholesterol or diosgenin) moieties with a carbamate linkage have been designed and synthesized for gene delivery. The gene transfection efficiency of two cationic lipids were found to be higher than that of commercially available Lipofectamine 2000. The lipoplexes formed from both cationic lipids were found to have low cytotoxicity in three cell lines even at high N/P ratios (see plot for H460 cells).

    7. Sequence-Specific Metallization of Single Divalent DNA–Nanoparticle Conjugates: A Potential Route to Single-Electron Devices (pages 592–597)

      Guoqing Wang, Ayako Ishikawa, Asumi Eguchi, Yasunobu Suzuki, Dr. Shukichi Tanaka, Dr. Yasutaka Matsuo, Dr. Kenichi Niikura and Prof. Kuniharu Ijiro

      Article first published online: 11 JUN 2012 | DOI: 10.1002/cplu.201200096

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      DNA-specific recognition: A conceptually new strategy for fabricating single-electron devices (SEDs) through programmable organization of DNA has been explored. Divalent DNA template primers that are conjugated to gold nanoparticles (AuNP) were prepared, followed by enzymatic synthesis of poly(dG)-poly(dC). By application of base-specific metallization, the divalent DNA–AuNP conjugates can be transformed into double-tunnel junction nanostructures (see figure).

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