9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds (pages 663–669)
Francesco Calogero, Stella Borrelli, Dr. Gaetano Speciale, Dr. Michael S. Christodoulou, Dr. Daniele Cartelli, Dr. Dario Ballinari, Dr. Francesco Sola, Dr. Clara Albanese, Dr. Antonella Ciavolella, Prof. Dr. Daniele Passarella, Prof. Dr. Graziella Cappelletti, Dr. Stefano Pieraccini and Prof. Dr. Maurizio Sironi
Article first published online: 13 MAY 2013 | DOI: 10.1002/cplu.201300036
Tubulin as the target: The introduction of a hydrophobic group at position 7 of 9-fluorenone-2-carboxylic acid (see structure) generates new tubulin binders, the design of which is suggested by modeling studies. The antiproliferative activity on two different cell lines, fluorescent microscopy, flow cytometry, and sedimentation assay tests confirmed the supposed mechanism.