Comparative Analysis of the Olfactory Properties of Silicon/Germanium/Tin Analogues of the Lily-of-the-Valley Odorants Lilial and Bourgeonal (pages 1747–1752)
Dr. Steffen Dörrich, Dr. Lian Gelis, Dr. Steffen Wolf, Dr. Astrid Sunderkötter, Christoph Mahler, Dr. Elena Guschina, Prof. Dr. Reinhold Tacke, Prof. Dr. Hanns Hatt and Dr. Philip Kraft
Article first published online: 18 SEP 2014 | DOI: 10.1002/cplu.201402160
What's in a scent? Silicon/germanium/tin analogues of lilial and bourgeonal are synthesized and characterized for their olfactory properties (see scheme). A HEK293 cell line with stable expression of hOR17-4 is used to analyze recombinant hOR17-4 activation by the respective analogues. This C/Si/Ge/Sn switch strategy is a powerful tool to extend our knowledge of structure–odor correlations in the family of lily-of-the-valley odorants.