In Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free-Radical Scavenging Activity and Oxidative Stress (pages 1083–1088)
Dr. Uschi M. Graham, Dr. Michael T. Tseng, Dr. Jacek B. Jasinski, Prof. Dr. Robert A. Yokel, Dr. Jason M. Unrine, Dr. Burtron H. Davis, Dr. Alan K. Dozier, Dr. Sarita S. Hardas, Dr. Rukhsana Sultana, Prof. Dr. Eric A. Grulke and Prof. Dr. D. Allan Butterfield
Version of Record online: 6 JUN 2014 | DOI: 10.1002/cplu.201402080
Liver detox: Ceria nanoparticles after ninety days inside the liver undergo in vivo processing that causes a shift towards smaller particle size and an increased reactive surface area with enhanced Ce3+ activity that leads to greater free-radical scavenging potential of the ultrafines (see figure). This is the first record showing that ceria undergoes partial dissolution inside the liver. Breakdown and redistribution could be a step towards improving ceria biocompatibility in vivo.