Original Paper

A modeling approach for the non-isothermal antisolvent crystallization of a solute with weak temperature dependent solubility

  1. D. J. Widenski1,
  2. A. Abbas2,*,
  3. J. A. Romagnoli2

Article first published online: 13 FEB 2012

DOI: 10.1002/crat.201100441

Issue

Crystal Research and Technology

Crystal Research and Technology

Volume 47, Issue 5, pages 491–504, May 2012

Additional Information

How to Cite

Widenski, D. J., Abbas, A. and Romagnoli, J. A. (2012), A modeling approach for the non-isothermal antisolvent crystallization of a solute with weak temperature dependent solubility. Cryst. Res. Technol., 47: 491–504. doi: 10.1002/crat.201100441

Author Information

  1. 1

    Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA

  2. 2

    School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia

*School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia

Publication History

  1. Issue published online: 4 MAY 2012
  2. Article first published online: 13 FEB 2012
  3. Manuscript Accepted: 3 FEB 2012
  4. Manuscript Revised: 2 FEB 2012
  5. Manuscript Received: 18 SEP 2011

Funded by

  • NSF Award #1132324

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Keywords:

  • crystallization;
  • antisolvent;
  • modeling;
  • optimization

Abstract

Antisolvent crystallization is a crystallization technique, which is normally operated isothermally. However, non-isothermal operation is on occasions performed for solutes that have temperature dependent solubility. This paper shows that it is beneficial to operate antisolvent crystallizers non-isothermally even for solutes whose solubility is weakly dependent on temperature. In this context, it demonstrates the joint control of particle mean size and size distribution coefficient of variation. A non-isothermal crystallization model-based framework is developed for the sodium chloride-ethanol-water system and validated for both isothermal and non-isothermal operations. This framework was used to systematically determine both the optimal antisolvent feed rate and temperature profiles that minimize the coefficient of variation while producing a specified mean crystal size. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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