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Original Paper
Correlating dynamic amino acid properties with success rate of crystallization of proteins from Bacteroides vulgatus
Article first published online: 13 FEB 2012
DOI: 10.1002/crat.201200007
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Yan, S. and Wu, G. (2012), Correlating dynamic amino acid properties with success rate of crystallization of proteins from Bacteroides vulgatus. Cryst. Res. Technol., 47: 511–516. doi: 10.1002/crat.201200007
Publication History
- Issue published online: 4 MAY 2012
- Article first published online: 13 FEB 2012
- Manuscript Accepted: 27 JAN 2012
- Manuscript Revised: 18 JAN 2012
- Manuscript Received: 5 JAN 2012
Funded by
- Guangxi Science Foundation (0991006Z, 10-046-06, 2010GXNSFF013003 and 11-031-11)
- Abstract
- References
- Cited By
Keywords:
- dynamic amino acid property;
- Bacteroides vulgatus;
- protein crystallization
Abstract
To enhance the success rate of protein crystallization, many studies were conducted to determine the relationship between amino acid properties and the success rate of protein crystallization. Although those were successful, new efforts should be made to search for the new factors, which affect protein crystallization. In this study, two dynamic amino acid properties were used to correlate with the success rate of crystallization of proteins from Bacteroides vulgatus, because the amino acid properties used in previous studies were steady. As previously done, logistic regression and neural network were used to model that relationship, and the results were compared against those obtained from each of 532 amino acid properties, which severed as benchmark. The results demonstrated that dynamic amino acid properties should be taken into consideration of protein crystallization. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)