Copper-Catalyzed Highly Efficient Aerobic Oxidation of Alcohols under Ambient Conditions



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Up the TEMPO: A novel, three-component catalyst system consisting of acetamido-TEMPO, copper bromide, and 4-pyrrolidinopyridine not only gives the highest reported turnover frequencies (up to 200 turnovers per hour) for solvent-free aerobic oxidation of primary alcohols to aldehydes at ambient temperature and pressure, but also displays exceptionally high selectivity toward benzylic and allylic primary alcohols.