Electrophilic Activation of Aldehydes “On Water”: A Facile Route to Dipyrromethanes



Shaken … and stirred: Dipyrromethane, an important building block in porphyrin chemistry, can be easily accessed by a reaction performed on water in the absence of Lewis acids. Thus, a variety of substituted dipyrromethanes were prepared in moderate to good yields using a range of aldehydes.

original image