1864-564X/asset/olbannerleft.gif?v=1&s=fc58be2772ff226734ef9ecf997ece0903885c67)
1864-564X/asset/olbannercenter.gif?v=1&s=da1d79329c83d74f32e7f59c9ec1b60f04484201)
1864-564X/asset/olbannerright.gif?v=1&s=5014c732b7ee11feab4c51d9cb84f12b575c99ce)
Review
Suzuki–Miyaura Cross-Coupling Reactions in Aqueous Media: Green and Sustainable Syntheses of Biaryls
Article first published online: 28 FEB 2010
DOI: 10.1002/cssc.200900221
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Polshettiwar, V., Decottignies, A., Len, C. and Fihri, A. (2010), Suzuki–Miyaura Cross-Coupling Reactions in Aqueous Media: Green and Sustainable Syntheses of Biaryls. ChemSusChem, 3: 502–522. doi: 10.1002/cssc.200900221
Publication History
- Issue published online: 14 MAY 2010
- Article first published online: 28 FEB 2010
- Manuscript Revised: 9 NOV 2009
- Manuscript Received: 17 SEP 2009
- Abstract
- Article
- References
- Cited By
Keywords:
- cross coupling;
- green chemistry;
- microwave chemistry;
- palladium;
- sustainable chemistry;
- water chemistry
Abstract
Carbon–carbon cross-coupling reactions are among the most important processes in organic chemistry, and Suzuki–Miyaura reactions are among the most widely used protocols for the formation of carbon–carbon bonds. These reactions are generally catalyzed by soluble palladium complexes with various ligands. However, the use of toxic organic solvents remains a scientific challenge and an aspect of economical and ecological relevance. This Review will summarize various recently developed significant methods by which the Suzuki–Miyaura coupling was conducted in aqueous media, and analyzes if they are “real green” protocols.