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Cyclopentyl Methyl Ether: An Alternative Solvent for Palladium-Catalyzed Direct Arylation of Heteroaromatics

Authors

  • Kassem Beydoun,

    1. Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes (France), Fax: (+33) 0223236939
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  • Dr. Henri Doucet

    Corresponding author
    1. Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes (France), Fax: (+33) 0223236939
    • Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes (France), Fax: (+33) 0223236939
    Search for more papers by this author

Abstract

Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as “greener” solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5–1 mol % of palladium catalysts at 125–150 °C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.

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