The concurrent decomposition and deoxygenation of ethanol was accomplished in a stratified reactor with 50–80 ms contact times. The stratified reactor comprised an upstream oxidation zone that contained Pt-coated Al2O3 beads and a downstream dehydration zone consisting of H-ZSM-5 zeolite films deposited on Al2O3 monoliths. Ethanol conversion, product selectivity, and reactor temperature profiles were measured for a range of fuel:oxygen ratios for two autothermal reactor configurations using two different sacrificial fuel mixtures: a parallel hydrogen–ethanol feed system and a series methane–ethanol feed system. Increasing the amount of oxygen relative to the fuel resulted in a monotonic increase in ethanol conversion in both reaction zones. The majority of the converted carbon was in the form of ethylene, where the ethanol carboncarbon bonds stayed intact while the oxygen was removed. Over 90 % yield of ethylene was achieved by using methane as a sacrificial fuel. These results demonstrate that noble metals can be successfully paired with zeolites to create a stratified autothermal reactor capable of removing oxygen from biomass model compounds in a compact, continuous flow system that can be configured to have multiple feed inputs, depending on process restrictions.