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A Synthetic Metabolic Pathway for Production of the Platform Chemical Isobutyric Acid

Authors

  • Prof. Kechun Zhang,

    Corresponding author
    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, Minneapolis, MN 55455 (USA), Fax: (+1) 612-626-7246
    • Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, Minneapolis, MN 55455 (USA), Fax: (+1) 612-626-7246
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  • Adam P. Woodruff,

    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, Minneapolis, MN 55455 (USA), Fax: (+1) 612-626-7246
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  • Mingyong Xiong,

    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, Minneapolis, MN 55455 (USA), Fax: (+1) 612-626-7246
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  • Jun Zhou,

    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, Minneapolis, MN 55455 (USA), Fax: (+1) 612-626-7246
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  • Yogesh K. Dhande

    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, Minneapolis, MN 55455 (USA), Fax: (+1) 612-626-7246
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Abstract

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Go green: Isobutyric acid is a high-volume industrial chemical produced from non-sustainable petroleum feedstocks and toxic materials. A synthetic metabolic pathway is constructed in E. coli to enable the biosynthesis of this compound from glucose, a renewable carbon source. The biosynthetic approach is an attractive option from both an economical and environmental point of view.

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