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Isohexide Derivatives from Renewable Resources as Chiral Building Blocks

Authors

  • Jing Wu,

    1. Food & Biobased Research, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen (The Netherlands), Fax: (+31) 317 483011
    2. Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Den Dolech 2, 5600 MB Eindhoven (The Netherlands)
    3. Dutch Polymer Institute (DPI), P.O. Box 902, 5600 AX Eindhoven (The Netherlands)
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  • Pieter Eduard,

    1. Food & Biobased Research, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen (The Netherlands), Fax: (+31) 317 483011
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  • Dr. Shanmugam Thiyagarajan,

    1. Food & Biobased Research, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen (The Netherlands), Fax: (+31) 317 483011
    2. Dutch Polymer Institute (DPI), P.O. Box 902, 5600 AX Eindhoven (The Netherlands)
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  • Dr. Jacco van Haveren,

    1. Food & Biobased Research, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen (The Netherlands), Fax: (+31) 317 483011
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  • Dr. Daan S. van Es,

    Corresponding author
    1. Food & Biobased Research, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen (The Netherlands), Fax: (+31) 317 483011
    2. Dutch Polymer Institute (DPI), P.O. Box 902, 5600 AX Eindhoven (The Netherlands)
    • Food & Biobased Research, Wageningen University, Bornse Weilanden 9, 6708 WG Wageningen (The Netherlands), Fax: (+31) 317 483011
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  • Prof. Dr. Cor E. Koning,

    1. Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Den Dolech 2, 5600 MB Eindhoven (The Netherlands)
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  • Dr. Martin Lutz,

    1. Bijvoet Center for Biomolecular Research, Crystal and Structural Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht (The Netherlands)
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  • Dr. Célia Fonseca Guerra

    1. Department of Theoretical Chemistry and Amsterdam Center for Multiscale Modeling (ACMM), Scheikundig Laboratorium der Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam (The Netherlands)
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Abstract

original image

Hextended family: A new family of C2/C5 carbon-extended isohexide derivatives is synthesized in a stereo-controlled manner with high purity and good yield. These chiral and rigid biobased building blocks can be widely applied: in pharmaceuticals, cholesteric liquid crystals, and as building blocks for high-performance polymers. The isoidide-based diacid is a potential renewable alternative to terephthalic acid.

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