Organocatalyzed Epoxidation of Alkenes in Continuous Flow using a Multi-Jet Oscillating Disk Reactor

Authors

  • Dr. Raffaele Spaccini,

    1. Department of Chemistry, University of Bergen, Allégaten 41, 5007 Bergen (Norway), Fax: (+47) 55 58 94 90
    2. Dipartimento di Chimica, Materiali e Ingegneria Chimica, “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano (Italy)
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  • Dr. Lucia Liguori,

    1. Fluens Synthesis, Thormøhlensgate 55, 5008 Bergen (Norway)
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  • Dr. Carlo Punta,

    1. Dipartimento di Chimica, Materiali e Ingegneria Chimica, “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano (Italy)
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  • Prof. Dr. Hans-René Bjørsvik

    Corresponding author
    1. Department of Chemistry, University of Bergen, Allégaten 41, 5007 Bergen (Norway), Fax: (+47) 55 58 94 90
    2. Fluens Synthesis, Thormøhlensgate 55, 5008 Bergen (Norway)
    • Department of Chemistry, University of Bergen, Allégaten 41, 5007 Bergen (Norway), Fax: (+47) 55 58 94 90
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Abstract

original image

The times are changing: A batch process, the Minisci epoxidation, is transformed into a continuous-flow protocol for the selective aerobic radical epoxidation of alkenes. The use of a novel reactor type allows to considerably shorten reactor residence times. Experimental results suggest that two different reaction mechanisms exist for the oxidation: one for the batch conditions and a different one for flow synthesis protocol.

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