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Keywords:

  • continuous flow reactors;
  • immobilization;
  • michael addition;
  • organocatalysis;
  • peptides
Thumbnail image of graphical abstract

Michael's peptides: A simple and efficient continuous flow technique has been developed for the organocatalytic Michael reactions using solid-supported peptidic catalysts, readily synthesized and immobilized in one single step. Synthetically useful chiral γ-nitroaldehydes have been obtained in excellent yields and stereoselectivities within short reaction times, while catalyst reusability, the ease of product isolation, and facile scale-up enhances the efficacy of the technique.