Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts

Michael's peptides: A simple and efficient continuous flow technique has been developed for the organocatalytic Michael reactions using solid-supported peptidic catalysts, readily synthesized and immobilized in one single step. Synthetically useful chiral γ-nitroaldehydes have been obtained in excellent yields and stereoselectivities within short reaction times, while catalyst reusability, the ease of product isolation, and facile scale-up enhances the efficacy of the technique.