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Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts

Authors

  • Sándor B. Ötvös,

    1. Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eötvös u. 6 (Hungary), Fax: (+36) 62-545705
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  • Dr. István M. Mándity,

    1. Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eötvös u. 6 (Hungary), Fax: (+36) 62-545705
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  • Prof. Dr. Ferenc Fülöp

    Corresponding author
    1. Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eötvös u. 6 (Hungary), Fax: (+36) 62-545705
    • Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eötvös u. 6 (Hungary), Fax: (+36) 62-545705
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Abstract

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Michael's peptides: A simple and efficient continuous flow technique has been developed for the organocatalytic Michael reactions using solid-supported peptidic catalysts, readily synthesized and immobilized in one single step. Synthetically useful chiral γ-nitroaldehydes have been obtained in excellent yields and stereoselectivities within short reaction times, while catalyst reusability, the ease of product isolation, and facile scale-up enhances the efficacy of the technique.

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