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The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

Authors

  • Trine P. Petersen,

    1. Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)
    2. Department of Physics and Chemistry, University of Southern Denmark, Odense (Denmark)
    3. Discovery Chemistry and DMPK, H. Lundbeck A/S, Valby (Denmark)
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  • Dr. Anastasios Polyzos ,

    1. Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)
    2. CSIRO, Materials Science and Engineering, Bayview Avenue, Clayton South, VIC 3169 (Australia)
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  • Dr. Matthew O'Brien,

    1. Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)
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  • Dr. Trond Ulven,

    1. Department of Physics and Chemistry, University of Southern Denmark, Odense (Denmark)
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  • Dr. Ian R. Baxendale,

    1. Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)
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  • Prof. Steven V. Ley

    Corresponding author
    1. Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)
    • Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge (UK)
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Abstract

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The gas is always greener: A continuous flow Glaser–Hay coupling reaction system, mediated by molecular oxygen, is developed based on a tube-in-tube gas/liquid reactor/injector. The system uses a semi-permeable Teflon AF-2400 membrane to effect rapid gas/liquid contact in flow, affording homogeneous solutions of oxygen. Measurements of out-gassing downstream of the back-pressure regulator indicate the onset of saturation is reached after about 16 seconds.

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