Solid-Supported Gallium Triflate: An Efficient Catalyst for the Three-Component Ketonic Strecker Reaction

Authors

  • Dr. Charlotte Wiles,

    Corresponding author
    1. Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen (The Netherlands), Fax: (+31) 464 75 94 16
    • Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen (The Netherlands), Fax: (+31) 464 75 94 16
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  • Dr. Paul Watts

    1. Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX (United Kingdom)
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Abstract

In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf)2) derivative as a means of increasing the cleanliness and cost effectiveness of using these increasingly expensive catalytic materials in synthetic processes. Having previously highlighted the advantages associated with coupling solid-supported catalysis and the emerging area of micro-reaction technology, we screened PS-Ga(OTf)2 for activity towards the ketonic Strecker reaction, in which the target α-aminonitriles were obtained in higher yield and purity compared to reactions reported in literature, in which the analogous homogeneous catalyst was used.

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