Communication

Ritter Reactions in Flow

  1. Logan Audiger1,
  2. Kevin Watts1,
  3. Simon C. Elmore1,
  4. Dr. Richard I. Robinson2,
  5. Prof. Thomas Wirth1,*

Article first published online: 1 DEC 2011

DOI: 10.1002/cssc.201100372

Issue

ChemSusChem

ChemSusChem

Special Issue: Flow Chemistry

Volume 5, Issue 2, pages 257–260, February 13, 2012

Additional Information

How to Cite

Audiger, L., Watts, K., Elmore, S. C., Robinson, R. I. and Wirth, T. (2012), Ritter Reactions in Flow. ChemSusChem, 5: 257–260. doi: 10.1002/cssc.201100372

Author Information

  1. 1

    School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT (UK), Fax: (+44) 29-2087-6968

  2. 2

    Novartis Horsham Research Centre, Global Discovery Chemistry, Wimblehurst Road, Horsham, West Sussex, RH12 5AB (UK)

*School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT (UK), Fax: (+44) 29-2087-6968

Publication History

  1. Issue published online: 15 FEB 2012
  2. Article first published online: 1 DEC 2011
  3. Manuscript Revised: 22 SEP 2011
  4. Manuscript Received: 15 JUL 2011

Funded by

  • Novartis
  • EPSRC
  • School of Chemistry, Cardiff University
  • University of Nantes

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Keywords:

  • amides;
  • carbocations;
  • medicinal chemistry;
  • microreactors;
  • Ritter reactions
Thumbnail image of graphical abstract

Flow me a Ritter: Ritter reactions are performed in a simple microreactor setup using tert-butylacetate as versatile carbocation source. The protocol avoids the handling of large amounts of hot concentrated sulfuric acid as low concentrations are optimal for rapid access tert-butyl- or diphenylmethyl-protected amides.

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