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Keywords:

  • amides;
  • carbocations;
  • medicinal chemistry;
  • microreactors;
  • Ritter reactions
Thumbnail image of graphical abstract

Flow me a Ritter: Ritter reactions are performed in a simple microreactor setup using tert-butylacetate as versatile carbocation source. The protocol avoids the handling of large amounts of hot concentrated sulfuric acid as low concentrations are optimal for rapid access tert-butyl- or diphenylmethyl-protected amides.