Sequential Continuous Flow Processes for the Oxidation of Amines and Azides by using HOF⋅MeCN

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Abstract

The generation and use of the highly potent oxidising agent HOFMeCN in a controlled single continuous flow process is described. Oxidations of amines and azides to corresponding nitrated systems by using fluorine gas, water and acetonitrile by sequential gas–liquid/liquid–liquid continuous flow procedures are reported.

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