Communication

Highly Efficient Heterogeneous Gold-catalyzed Direct Synthesis of Tertiary and Secondary Amines from Alcohols and Urea

  1. Lin He,
  2. Yue Qian,
  3. Ran-Sheng Ding,
  4. Dr. Yong-Mei Liu,
  5. Prof. Dr. He-Yong He,
  6. Prof. Kang-Nian Fan,
  7. Prof. Dr. Yong Cao*

Article first published online: 13 MAR 2012

DOI: 10.1002/cssc.201100581

Issue

ChemSusChem

ChemSusChem

Volume 5, Issue 4, pages 621–624, April 2012

Additional Information

How to Cite

He, L., Qian, Y., Ding, R.-S., Liu, Y.-M., He, H.-Y., Fan, K.-N. and Cao, Y. (2012), Highly Efficient Heterogeneous Gold-catalyzed Direct Synthesis of Tertiary and Secondary Amines from Alcohols and Urea. ChemSusChem, 5: 621–624. doi: 10.1002/cssc.201100581

Author Information

  1. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774

*Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Handan Road 220, Shanghai 200433 (PR China), Fax: (+86) 21-65643774

Publication History

  1. Issue published online: 30 MAR 2012
  2. Article first published online: 13 MAR 2012
  3. Manuscript Revised: 1 NOV 2011
  4. Manuscript Received: 19 SEP 2011

Funded by

  • National Natural Science Foundation of China. Grant Numbers: 20873026, 21073042
  • New Century Excellent Talents in the University of China. Grant Number: NCET-09-0305
  • National Basic Research Program of China. Grant Number: 2009CB623506
  • Science & Technology Commission of Shanghai Municipality. Grant Number: 08DZ2270500

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Keywords:

  • alcohols;
  • amination;
  • amines;
  • gold;
  • nanoparticles
Thumbnail image of graphical abstract

Urea, the white gold: The efficient synthesis of tertiary and secondary amines is achieved by heterogeneous gold-catalyzed direct amination of stoichiometric alcohols with urea in good to excellent yields. Via a hydrogen autotransfer pathway, the reactions of primary alcohols with urea give tertiary amines exclusively, while secondary alcohols selectively afford secondary amines.

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