Communication

Ruthenium-catalyzed [2+2+2] Cycloaddition of Diynes with Nitriles in Pure Water

  1. Fen Xu,
  2. Chunxiang Wang,
  3. Dr. Xincheng Li,
  4. Prof. Dr. Boshun Wan*

Article first published online: 13 MAR 2012

DOI: 10.1002/cssc.201100744

Issue

ChemSusChem

ChemSusChem

Special Issue: Sustainability Research in Dalian

Volume 5, Issue 5, pages 854–857, May 2012

Additional Information

How to Cite

Xu, F., Wang, C., Li, X. and Wan, B. (2012), Ruthenium-catalyzed [2+2+2] Cycloaddition of Diynes with Nitriles in Pure Water. ChemSusChem, 5: 854–857. doi: 10.1002/cssc.201100744

Author Information

  1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (PR China), Fax: (+86) 0411-84379223

*Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (PR China), Fax: (+86) 0411-84379223

Publication History

  1. Issue published online: 10 MAY 2012
  2. Article first published online: 13 MAR 2012
  3. Manuscript Received: 19 NOV 2011

Funded by

  • National Basic Research Program of China. Grant Number: 2010CB833300
  • National Natural Science Foundation of China. Grant Number: 21172218

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Keywords:

  • cycloaddition;
  • nitrile;
  • pyridine;
  • ruthenium;
  • water
Thumbnail image of graphical abstract

One ring to bind them: An efficient method for synthesizing highly functionalized pyridine derivatives from diynes and nitriles is described. The reaction system involves Cp*Ru(COD)Cl/tppts-catalyzed [2+2+2] cycloaddition in pure water. Without being accompanied by diyne dimerization or trimerization byproducts, the desired products can be obtained in moderate to high yields.

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