Ruthenium-catalyzed [2+2+2] Cycloaddition of Diynes with Nitriles in Pure Water

Authors

  • Fen Xu,

    1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (PR China), Fax: (+86) 0411-84379223
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  • Chunxiang Wang,

    1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (PR China), Fax: (+86) 0411-84379223
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  • Dr. Xincheng Li,

    1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (PR China), Fax: (+86) 0411-84379223
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  • Prof. Dr. Boshun Wan

    Corresponding author
    1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (PR China), Fax: (+86) 0411-84379223
    • Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (PR China), Fax: (+86) 0411-84379223
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Abstract

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One ring to bind them: An efficient method for synthesizing highly functionalized pyridine derivatives from diynes and nitriles is described. The reaction system involves Cp*Ru(COD)Cl/tppts-catalyzed [2+2+2] cycloaddition in pure water. Without being accompanied by diyne dimerization or trimerization byproducts, the desired products can be obtained in moderate to high yields.

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