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Keywords:

  • cycloaddition;
  • nitrile;
  • pyridine;
  • ruthenium;
  • water
Thumbnail image of graphical abstract

One ring to bind them: An efficient method for synthesizing highly functionalized pyridine derivatives from diynes and nitriles is described. The reaction system involves Cp*Ru(COD)Cl/tppts-catalyzed [2+2+2] cycloaddition in pure water. Without being accompanied by diyne dimerization or trimerization byproducts, the desired products can be obtained in moderate to high yields.