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Solvent-Free Palladium-Catalyzed Direct Arylation of Heteroaromatics with Aryl Bromides

Authors

  • Souhila Bensaid,

    1. Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes (France), Fax: +(33) 0223236939
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  • Dr. Henri Doucet

    Corresponding author
    1. Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes (France), Fax: +(33) 0223236939
    • Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes (France), Fax: +(33) 0223236939
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Abstract

Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol %) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides.

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